Réunion

Journée thématique Imagerie vasculaire 2026

Annonce

Nous proposons cette deuxième édition avec la volonté de soutenir les actions pluridisciplinaires à l’interface entre les activités de recherche du GDR (apprentissage artificiel, traitement du signal, vision artificielle) et les problématiques cliniques en lien avec l’imagerie vasculaire. De plus, nous souhaitons mettre en valeur la valorisation industrielle, les développements reproductibles et open-source pouvant bénéficier au plus grand nombre dans les communautés scientifiques et médicales.

Les thèmes abordés sont, sans être exhaustif :

• Imagerie médicale, radiologie vasculaire, cardiaque, hépatique, etc.
• Thérapies guidées par l’image, technologies médicales
• Analyse et traitement d’images médicales et biomédicales
• Apprentissage artificiel pour l’imagerie médicale et la simulation
• Développement logiciel open-source
• Simulation et modélisation numériques de mécanismes biologiques
• Annotation automatique ou assistée de données médicales

Cette journée pourrait donc concerner des chercheurs en traitement du signal, en informatique, en vision artificielle, en mathématiques appliquées, etc. et des médecins en radiologie vasculaire ou en chirurgie vasculaire par exemple.

Comité d’organisation

• Antoine Vacavant, Institut Pascal, Université Clermont Auvergne, antoine.vacavant@uca.fr
• Bertrand Kerautret, LIRIS, Université Lumière Lyon 2, bertrand.kerautret@univ-lyon2.fr
• Nicolas Passat, CReSTIC, Université de Reims Champagne Ardenne, nicolas.passat@univ-reims.fr

Programme de la journée

La journée sera ponctuée par 3 conférences invitées :

• Une conférence scientifique : Marcela SZOPOS – MAP5 / Univ. Paris Cité
  Titre : Combining Physics-Based Modeling and Data Analytics Methods To Develop a Digital Twin for Ocular Applications
  Résumé : Understanding the behavior of the human eye is challenging due to the complex interactions between various physical phenomena, such as fluid dynamics, the deformation of surrounding tissues and the impact of their temperature. Although medical data can offer valuable insights into ocular physiopathology, the available information can be scarce and noisy. Moreover, in experimental studies, multiple factors come into play and it is difficult to isolate the contributions of individual mechanisms. Therefore, developing a robust and accurate digital twin for ocular applications can enhance our understanding of this complex system, by integrating governing mechanisms and data variability.
  This talk presents our ongoing efforts in this direction. First, we focus on assessing the combined effects of ocular blood flow and different ocular tissues by means of a coupled multiscale hemodynamics and biomechanics model [1]. Secondly, building upon previous developments in retinal blood flow modeling, we integrate clinical measurements and physiological insights with the aim of providing a robust, clinically relevant analysis of waveform parameters in the retinal vasculature [2]. Finally, we highlight the potential of the model for studying cardiovascular diseases with ocular manifestations [3]. We will illustrate these developments, discuss their applications in ocular physiology and treatment, and address remaining challenges, including inverse problems and parameter identification.
  [1] L. Sala et al. The ocular mathematical virtual simulator: A validated multiscale model for hemodynamics and biomechanics in the human eye, Int. J. Numer. Meth. Biomed. Engng. (2024).
  [2] L. Sala et al. Analysis of waveform parameters in the retinal vasculature via mathematical modeling and data analytics methods, La Matematica (2024).
  [3] L. Sala et al. Eye2Heart: A reduced mathematical model bridging cardiovascular and ocular hemodynamics, Math. Biosci. Engng (2026).
  
• Une conférence médicale : Guillaume CANAUD – Institut Necker-Enfants malades
  Titre : From a single patient to a US FDA approved drug: the story of a drug repositioning for a rare disease
  Résumé : CLOVES syndrome (congenital lipomatous overgrowth, vascular malformations, epidermal naevi, scoliosis/skeletal and spinal syndrome) is a genetic disorder that results from somatic, mosaic gain-of-function mutations of the PIK3CA gene, and belongs to the spectrum of PIK3CA-related overgrowth syndromes (PROS). This rare condition has no specific treatment and a poor survival rate. Here, we describe a postnatal mouse model of PROS/CLOVES that partially recapitulates the human disease, and demonstrate the efficacy of BYL719, an inhibitor of PIK3CA, in preventing and improving organ dysfunction. On the basis of these results, we used BYL719 to treat nineteen patients with PROS. The drug improved the disease symptoms in all patients. Previously intractable vascular tumours became smaller, congestive heart failure was improved, hemihypertrophy was reduced, and scoliosis was attenuated. The treatment was not associated with any substantial side effects. In conclusion, this study provides the first direct evidence supporting PIK3CA inhibition as a promising therapeutic strategy in patients with PROS.
  
• Une conférence industrielle : Laurence ROUET – SIEMENS
  Titre : Vascular image quantification
  Résumé : The presentation will focus on two arterial territories associated with different pathological conditions. In a first part, we will present atherosclerosis and the imaging modalities used for patient monitoring. Then we will explain how carotid plaque quantification is associated to cardio-vascular events and present the successive steps that enabled to build an AI model of plaque. In a second part, we will present an approach for the quantification of abdominal aortic strain in the context of better assessment of the risk of wall rupture. We will present the required imaging acquisitions, their processing and how the results can contribute to better tissue characterization.
  Finally, we will open research perspectives related to the new advanced vascular imaging lab that we are setting up with INSERM and CHU Nantes, in a public-private partnership with Siemens Healthineers.
  

Le planning complet est le suivant :

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Dates importantes